通过计算P-value评价SNP组合模型，从而找出复杂疾病原因-By calculating the P-value assessment of SNP combination model, in order to identify causes of complex diseases

1.用隐马尔科夫模型（HMM）模拟肿瘤细胞整个染色体的拷贝数（CN）变异。并用viteri算法得到最可能的（CN）状态转移序列； 2.使用baum welch算法根据所给序列数据和初始状态转移矩阵，重新估算状态转移矩阵。-HMM, Hidden Markov, baulm welch, viterbi, SNP-array

Samtools is a suite of programs for interacting with high-throughput sequencing data. It consists of three separate repositories: SamtoolsReading/writing/editing/indexing/viewing SAM/BAM/CRAM format BCFtoolsReading/writing BCF2/VCF/gVCF files and c